IOMM-LeeHomo sapiens (Human)Cancer cell line
Also known as: IntraOsseous Malignant Meningioma-Lee, IOMMLEE, IOMM Lee, Iomm-Lee, IOMM-LEE
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_5779 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain[UBERON:UBERON_0000955] |
Donor Information
| Age | 61 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Meningioma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Meningioma |
| OncoTree Code | MNG |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000629_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
9,10
D13S317
8,9
D16S539
12,13
D5S818
11,13
D7S820
11,12
TH01
6,7
TPOX
8,11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Tumor-derived cell culture model for the investigation of meningioma biology.
Anderson M.P., Uhlmann E.N., Kipper F.C., Krichevsky A.M.
J. Neuropathol. Exp. Neurol. 80:1117-1124(2021).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Genomic profile of human meningioma cell lines.";
Dunn I.F.
PLoS ONE 12:E0178322-E0178322(2017).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A comparison of the cell lines used in meningioma research.";
Jensen R.L.
Surg. Neurol. 70:295-307(2008).
A genetic strategy to overcome the senescence of primary meningioma cell cultures.
VandenBerg S.R., Feuerstein B.G., Deen D.F., McDermott M.W., Lal A.
J. Neurooncol. 78:113-121(2006).