Ishikawa (Heraklio) 02 ER-Homo sapiens (Human)Cancer cell line
Also known as: ER-02 ISH, ISHIKAWAHERAKLIO02ER, Ishikawa(Heraklio)02ER-
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_6543 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Endometrium[UBERON:UBERON_0001295] |
Donor Information
| Age | 39 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Type I endometrial adenocarcinoma |
|---|---|
| Lineage | Uterus |
| Subtype | Endometrial Carcinoma |
| OncoTree Code | UCEC |
DepMap Information
| Source Type | ECACC |
|---|---|
| Source ID | ACH-000961_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Met246Val (c.736A>G) | Unspecified | - | PubMed=27693639 |
| MutationSimple | TP53 | p.Asp49His (c.145G>C) | Heterozygous | - | from parent cell line Ishikawa |
| MutationSimple | PTEN | p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3) | Homozygous | - | PubMed=33391433 |
| MutationSimple | PTEN | p.Glu288fs*3 (c.863delA) | Heterozygous | - | Unknown |
| MutationSimple | POLE | p.Asn751fs (c.2252delA) | Heterozygous | - | from parent cell line Ishikawa |
| MutationSimple | POLE | p.Pro102Ser (c.304C>T) | Heterozygous | - | from parent cell line Ishikawa |
| MutationSimple | PIK3R1 | p.Leu570Pro (c.1709T>C) | Heterozygous | - | from parent cell line Ishikawa |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,12
D13S317
9,12,13
D16S539
9
D18S51
13,14,18,19,20
D21S11
28
D3S1358
15,16,17
D5S818
10,11,12
D7S820
9,10
D8S1179
12,16
FGA
20,21
Penta D
10,11
Penta E
11,12,18,19,20
TH01
9,10
TPOX
8
vWA
14,16,17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).