CHLA-136Homo sapiens (Human)Cancer cell line
Also known as: CHLA_136
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_6590 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 3 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
Disease Information
| Disease | Neuroblastoma |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Neuroblastoma |
| OncoTree Code | NBL |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001465_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationNone reported | TP53 | - | - | - | PubMed=19787792 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
8,11
D16S539
9,12
D18S51
12,18
D19S433
13,14
D21S11
31.2,32.2
D2S1338
23,25
D3S1358
15,18
D5S818
9,12
D7S820
8
D8S1179
10,13
FGA
23,25
TH01
7
TPOX
8,11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
Lau L.M.S.
J. Neurooncol. 119:17-26(2014).
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Nat. Genet. 45:12-17(2013).
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Reynolds C.P.
Pediatr. Blood Cancer 56:239-249(2011).
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Gomer C.J., Triche T.J., Reynolds C.P.
Cancer Res. 61:6185-6193(2001).
Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma.
Brodeur G.M., White P.S.
Cancer Res. 61:679-686(2001).