WM3211Homo sapiens (Human)Cancer cell line
Also known as: EST79, WC00045, WM 3211, WM-3211
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_6797 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 34 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Acral lentiginous melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Acral Melanoma |
| OncoTree Code | ACRM |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-002508_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys242Gly (c.724T>G) | Unspecified | - | PubMed=23851445, PubMed=17260012 |
| MutationSimple | KIT | p.Leu576Pro (c.1727T>C) | Unspecified | - | PubMed=24576830, PubMed=23851445, Wistar |
| MutationSimple | CDKN2A | p.Gln50Ter (c.148C>T) | Unspecified | - | PubMed=23851445 |
| MutationNone reported | BRAF | - | - | - | Wistar |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
13
D13S317
12
D16S539
12
D18S51
12
D19S433
13,14
D21S11
29,31.2
D2S1338
20,24
D3S1358
15,16
D5S818
11
D7S820
10,12
D8S1179
10,11
FGA
20
TH01
6,9.3
TPOX
11
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Rosen N., Solit D.B.
Cancer Res. 74:2340-2350(2014).
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Borg A., Pawelec G., Guldberg P.
Mol. Cancer Res. 11:1166-1178(2013).
Genomic characterisation of acral melanoma cell lines.";
Marais R.
Pigment Cell Melanoma Res. 25:488-492(2012).
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Nathanson K.L.
Cancer Res. 68:5743-5752(2008).
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Guldberg P., Borg A.
Oncogene 26:4738-4748(2007).
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Dummer R.
Pigment Cell Res. 19:290-302(2006).