WM983BHomo sapiens (Human)Cancer cell line
Also known as: WC00066, WM-983/B, WM983-B, WM 983B, WM-983B
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_6809 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Inguinal lymph node[UBERON:UBERON_0001542] |
Donor Information
| Age | 54 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000765_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Pro278Phe (c.832_833CC>TT) | Homozygous | - | from parent cell line WM983B |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
12
D16S539
11,12
D19S433
10,14
D21S11
29,31.2
D2S1338
25,27
D3S1358
17
D5S818
11
D7S820
11
D8S1179
8,13
FGA
20,23
TH01
6
TPOX
11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Functional profiling of live melanoma samples using a novel automated platform.
Schuchter L.M., Clark D.P.
PLoS ONE 7:E52760-E52760(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Sosman J.A., Nathanson K.L., Herlyn M.
Cancer Cell 18:683-695(2010).
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Nathanson K.L.
Cancer Res. 68:5743-5752(2008).
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Dummer R.
Pigment Cell Res. 19:290-302(2006).
Human melanoma: development and progression.";
Herlyn M.
Cancer Metastasis Rev. 9:101-112(1990).