MOLM-14Homo sapiens (Human)Cancer cell line
Also known as: MOLM14, Molm14, Molm 14, Molm-14
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_7916 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 20 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Acute myeloid leukemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Acute Myeloid Leukemia |
| OncoTree Code | AML |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-001574_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationUnexplicit | FLT3 | Internal tandem duplication (FLT3-ITD) | Unspecified | - | PubMed=12529668 |
| Gene fusion | KMT2A | KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 | - | - | PubMed=31701557 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
10,11
D16S539
10,11
D18S51
13,15
D19S433
12,14
D21S11
30,31
D2S1338
23,25
D3S1358
15
D5S818
10,11
D7S820
10,12
D8S1179
13,14
FGA
21,23
Penta D
9,12
Penta E
18,19
TH01
7
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Survey of activated FLT3 signaling in leukemia.";
Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.
PLoS ONE 6:E19169-E19169(2011).
FLT3 mutations in acute myeloid leukemia cell lines.";
Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.
Leukemia 17:120-124(2003).
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23).
Katayama Y., Kimura G., Fujii N., Omoto E., Harada M., Orita K.
Leukemia 11:1469-1477(1997).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).