21NTHomo sapiens (Human)Cancer cell line
Also known as: 21 NT
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_7933 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Breast[UBERON:UBERON_0000310] |
Donor Information
| Age | 36 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Subtype Features | HER2+ |
Disease Information
| Disease | Breast carcinoma |
|---|---|
| Lineage | Breast |
| Subtype | Breast Invasive Ductal Carcinoma |
| OncoTree Code | IDC |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-002399_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Ser33Phefs*9 (c.96_97insT) | Unspecified | - | PubMed=7923592 |
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Publications
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
Modeling precision treatment of breast cancer.";
Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Genome Biol. 14:R110.1-R110.14(2013).
Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns.
Al-Katib W., Leong H.S., Rodenhiser D.I., Chambers A.F., Tuck A.B.
Lab. Invest. 90:1247-1258(2010).
Alterations in growth phenotype and radiosensitivity after fractionated irradiation of breast carcinoma cells from a single patient.
Wazer D.E., Joyce M., Jung L., Band V.
Int. J. Radiat. Oncol. Biol. Phys. 26:81-88(1993).
Tumor cell-specific loss of p53 protein in a unique in vitro model of human breast tumor progression.
Liu X.-L., Band H., Gao Q.-S., Wazer D.E., Chu Q.-M., Band V.
Carcinogenesis 15:1969-1973(1994).
Tumor progression in four mammary epithelial cell lines derived from the same patient.
Connolly J.L., Sager R.
Cancer Res. 50:7351-7357(1990).
Cell lines from human breast.";
Leibovitz A.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York; USA (1994).
Tumor progression in breast cancer.";
Band V., Sager R.
(In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.169-178; Humana Press; New York; USA (1990).