YAMN-73Homo sapiens (Human)Cancer cell line
Also known as: YAManashi-N-73, YAMN73
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_8015 |
|---|---|
| Species | Homo sapiens (Human) |
Disease Information
| Disease | B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Gln (c.743G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=20575032 |
| Gene fusion | ABL1 | BCR-ABL1, BCR-ABL | - | BCR exon 1 fused to ABL1 exon 2 | PubMed=10576511, PubMed=10071072, PubMed=8751477 |
Publications
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
Minegishi M., Iwamoto S., Sugita K., Inukai T.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Sugita K., Hosoi H.
Int. J. Hematol. 108:312-318(2018).
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Tada M., Moriuchi T., Sugita K.
Am. J. Hematol. 85:535-537(2010).
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.
Blood 116:962-970(2010).
TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.
Koyama-Okazaki T., Suzuki T., Sugita K., Nakazawa S.
Blood 101:3658-3667(2003).
Participation of granulocyte colony-stimulating factor in the growth regulation of leukemia cells from Philadelphia chromosome-positive acute leukemia and blast crisis of chronic myeloid leukemia.
Koyama-Okazaki T., Nakazawa S.
Leukemia 14:1386-1395(2000).