G-415Homo sapiens (Human)Cancer cell line
Also known as: G415
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_8198 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Donor Information
| Age | 68 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Carcinoma of gallbladder and extrahepatic biliary tract |
|---|---|
| Lineage | Biliary Tract |
| Subtype | Gallbladder Adenocarcinoma, NOS |
| OncoTree Code | GBAD |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-001850_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | KRAS | p.Gly13Asp (c.38G>A) | Heterozygous | Somatic | from parent cell line MDA-MB-231 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
8,10
D16S539
12
D18S51
12,14
D21S11
32.2
D3S1358
15,17
D5S818
12
D7S820
11,12
D8S1179
12,14
FGA
21,24
Penta D
9
Penta E
12,14
TH01
7
TPOX
11
vWA
15,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
Vazquez F., Getz G., Bardeesy N.M.
bioRxiv 2024:07.04.601970-07.04.601970(2024).
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.
Cancers (Basel) 12:2510.1-2510.14(2020).
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.
Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.
Biol. Res. 53:13.1-13.17(2020).
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Bardeesy N.M.
Cancer Discov. 6:727-739(2016).
Exogenous expression of E-cadherin in gallbladder carcinoma cell line G-415 restores its cellular polarity and differentiation.
Jiao W., Miyazaki K., Kitajima Y.
Int. J. Oncol. 19:1099-1107(2001).