YAPHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_8467 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Disease Information
| Disease | Acute monoblastic/monocytic leukemia |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | WT1 | p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T) | Heterozygous | Somatic | from parent cell line U-937 |
| MutationSimple | TP53 | c.559+1G>A (p.Val173Trpfs*59) | Homozygous | Splice donor mutation | from parent cell line U-937 |
| MutationSimple | PTPN11 | p.Gly60Arg (c.178G>C) | Heterozygous | - | from parent cell line U-937 |
| MutationSimple | PTEN | p.Gly129fs*51 (c.387_388insCGCC) | Hemizygous | - | from parent cell line U-937 |
| Gene fusion | MLLT10 | PICALM-MLLT10, CALM-AF10 | - | - | from parent cell line U-937 |
Publications
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Freshney R.I.
Int. J. Cancer 127:1-8(2010).
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
Leukemia 17:416-426(2003).