UW228Homo sapiens (Human)Cancer cell line
Also known as: HBT228, HBT 228, UW 228
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_8585 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain, posterior fossa[UBERON:UBERON_0008788] |
Donor Information
| Age | 9 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Subtype Features | MYC_No |
Disease Information
| Disease | Medulloblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Medulloblastoma |
| OncoTree Code | MBL |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001232_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Thr155Asn (c.464C>A) | Unspecified | - | from parent cell line UW228 |
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Publications
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data Brief 9:696-698(2016).
In vitro models of medulloblastoma: choosing the right tool for the job.
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
J. Biotechnol. 236:10-25(2016).
BET bromodomain inhibition of MYC-amplified medulloblastoma.";
Bradner J.E., Beroukhim R., Cho Y.-J.
Clin. Cancer Res. 20:912-925(2014).
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.
Pomeroy S.L., Cho Y.-J.
Neuro-oncol. 13:165-175(2011).
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuro-oncol. 12:1244-1256(2010).
Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.
Lo H.-W., Stephenson L., Cao X.-Y., Milas M., Pollock R.E., Ali-Osman F.
Mol. Cancer Res. 6:843-850(2008).
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
Mullapudi S.R.S., Ali-Osman F., Shou J., Srivenugopal K.S.
Biochem. J. 351:393-402(2000).
Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.
Srivenugopal K.S., Mullapudi S.R.S., Shou J., Hazra T.K., Ali-Osman F.
Cancer Res. 60:282-287(2000).
Brain tumors.";
Ali-Osman F.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).