HS-Sch-2Homo sapiens (Human)Cancer cell line
Also known as: HSSCH2, HS-sch-2
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_8718 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral nervous system, left sciatic nerve[UBERON:UBERON_0001322] |
Donor Information
| Age | 54 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Malignant peripheral nerve sheath tumor |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Malignant Peripheral Nerve Sheath Tumor |
| OncoTree Code | MPNST |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-002066_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg273His (c.818G>A) | Homozygous | - | Unknown, PubMed=16264262 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,13
D13S317
11
D16S539
11,12
D18S51
13
D19S433
10.2,14.2
D21S11
29,30
D2S1338
20
D3S1358
18
D5S818
13
D7S820
8,11
D8S1179
14
FGA
23,26
TH01
6,7
TPOX
8
vWA
15,16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.
Wilson R.C., Carroll A.J. 3rd, Wolff D.J., Roth K.A., Carroll S.L.
Sci. Rep. 11:5690-5690(2021).
Genetics of human malignant peripheral nerve sheath tumors.";
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Neurooncol. Adv. 2:i50-i61(2020).
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
Lothe R.A.
Mol. Oncol. 11:1156-1171(2017).