WM793Homo sapiens (Human)Cancer cell line
Also known as: WC00062, WM793b, WM 793B, WM-793B, WM793B, WML 793, WM 793, WM-793
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_8787 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Skin[UBERON:UBERON_0002097] |
Donor Information
| Age | 37 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Cutaneous melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-000827_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | PTEN | p.Trp274Ter (c.821G>A) | Heterozygous | - | from parent cell line WM793 |
| MutationSimple | CDK4 | p.Lys22Gln (c.64A>C) | Homozygous | - | from parent cell line WM793 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Standard melanoma-associated markers do not identify the MM127 metastatic melanoma cell line.
Haridas P., McGovern J.A., Kashyap A.S., McElwain D.L.S., Simpson M.J.
Sci. Rep. 6:24569-24569(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Rosen N., Solit D.B.
Cancer Res. 74:2340-2350(2014).
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Borg A., Pawelec G., Guldberg P.
Mol. Cancer Res. 11:1166-1178(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Nathanson K.L.
Cancer Res. 68:5743-5752(2008).
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Dummer R.
Pigment Cell Res. 19:290-302(2006).
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Garrido F.
Cancer Immunol. Immunother. 54:141-148(2005).
Isolation of the melanoma-associated antigen p23 using antibody phage display.
Deen K., Linnenbach A., Somasundaram R., Swoboda R.K., Herlyn D.
J. Immunol. 166:432-438(2001).
Growth and invasion of human melanomas in human skin grafted to immunodeficient mice.
Herlyn D., Valyi-Nagy I.T., Herlyn M.
Am. J. Pathol. 143:528-537(1993).
Variant sublines of early-stage human melanomas selected for tumorigenicity in nude mice express a multicytokine-resistant phenotype.
Kerbel R.S.
Am. J. Pathol. 144:776-786(1994).
Characteristics of cultured human melanocytes isolated from different stages of tumor progression.
Koprowski H.
Cancer Res. 45:5670-5676(1985).
Human melanoma: development and progression.";
Herlyn M.
Cancer Metastasis Rev. 9:101-112(1990).