STS-26THomo sapiens (Human)Cancer cell line
Also known as: STS26, STS26T
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_8917 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone, left scapula[UBERON:UBERON_0006849] |
Donor Information
| Age | 51 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Malignant peripheral nerve sheath tumor |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Malignant Peripheral Nerve Sheath Tumor |
| OncoTree Code | MPNST |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-002695_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene deletion | TP53 | - | Homozygous | 2 out of 3 copies | from parent cell line HL-60 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.
Wilson R.C., Carroll A.J. 3rd, Wolff D.J., Roth K.A., Carroll S.L.
Sci. Rep. 11:5690-5690(2021).
Genetics of human malignant peripheral nerve sheath tumors.";
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Neurooncol. Adv. 2:i50-i61(2020).
Deregulated microRNAs in neurofibromatosis type 1 derived malignant peripheral nerve sheath tumors.
French P.J., van Royen M.E., Taal W., Sleijfer S., Wiemer E.A.C.
Sci. Rep. 10:2927-2927(2020).
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
Lothe R.A.
Mol. Oncol. 11:1156-1171(2017).
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Field J.
Am. J. Cancer Res. 7:923-934(2017).
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014).
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.
Mautner V.-F., von Deimling A.
PLoS ONE 8:E57152-E57152(2013).
Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy.
Sun D., Tainsky M.A., Haddad R.
Transl. Oncogenomics 5:1-7(2012).
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.
Lev D.C.
Cancer Res. 71:185-196(2011).
Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Watson M.A., Perry A., Gutmann D.H., Ratner N.
Cancer Res. 66:2584-2591(2006).
The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines.
Nowak J.E., Benjamins J.A., Tainsky M.A., Reiners J.J. Jr.
J. Pharmacol. Exp. Ther. 316:456-465(2006).
Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB.
Badache A., de Vries G.H.
J. Cell. Physiol. 177:334-342(1998).