YD-10BHomo sapiens (Human)Cancer cell line
Also known as: YD10B
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_8929 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Oral cavity, tongue[UBERON:UBERON_0001723] |
Donor Information
| Age | 67 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Squamous cell carcinoma of the oral tongue |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | KCLB |
|---|---|
| Source ID | ACH-000723_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Tyr236Ter (c.708C>A) | Homozygous | Acquired spontaneously at 90 PDL | Unknown, PubMed=16264262 |
| MutationSimple | CDKN2A | p.Trp110Ter (c.330G>A) (p.Gly125Arg, c.373G>A) | Heterozygous | - | Unknown |
| MutationSimple | CDKN2A | p.Glu88Ter (c.262G>T) | Heterozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12,13
D13S317
8,9
D16S539
10,11
D18S51
14
D21S11
30,32
D3S1358
17
D5S818
11,13
D7S820
11
D8S1179
11
DXS101
22
DYS391
10
FGA
23
Penta D
8,9
Penta E
5,8
TH01
6,9
TPOX
8
vWA
18,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Molecular genetic characterization of p53 mutated oropharyngeal squamous cell carcinoma cells transformed with human papillomavirus E6 and E7 oncogenes.
Jung C.-K., Park W.-S., Nam S.-W., Eun J.-W., Kang J.-H.
Int. J. Oncol. 43:383-393(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
The cyclooxygenase-2 selective inhibitor celecoxib suppresses proliferation and invasiveness in the human oral squamous carcinoma.
Kwak Y.E., Jeon N.K., Kim J., Lee E.J.
Ann. N. Y. Acad. Sci. 1095:99-112(2007).