NCI-H684Homo sapiens (Human)Cancer cell line
Also known as: NCIH684, H-684, H684
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_9980 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Colon adenocarcinoma |
|---|---|
| Lineage | Bowel |
| Subtype | Colon Adenocarcinoma |
| OncoTree Code | COAD |
DepMap Information
| Source Type | KCLB |
|---|---|
| Source ID | ACH-000089_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly245Ser (c.733G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=28445466 |
| MutationSimple | KRAS | p.Gly12Asp (c.35G>A) | Unspecified | - | PubMed=29786757 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10
D13S317
8,12
D16S539
11,12
D21S11
31.2
D3S1358
17,18
D5S818
11
D7S820
10,11
FGA
23
TH01
9
TPOX
8,9
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
Nat. Commun. 6:7002.1-7002.10(2015).
NCI-Navy Medical Oncology Branch cell line data base.";
Carney D.N., Minna J.D., Mulshine J.L.
J. Cell. Biochem. Suppl. 24:32-91(1996).
Characteristics of cell lines established from human colorectal carcinoma.
Johnson B.E., Gazdar A.F.
Cancer Res. 47:6710-6718(1987).