RCHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_9U45 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 71 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | High grade B-cell lymphoma with MYC and/or BCL2 and/or BCL6 rearrangement |
|---|---|
| Lineage | Lymphoid |
| Subtype | Germinal Center B-Cell Type |
| OncoTree Code | GCB |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-003106_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | IGH | MYC-IGH | - | - | PubMed=31160637 |
| Gene fusion | BCL2 | IGH-BCL2 | - | - | from parent cell line SU-DHL-4 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,12
D13S317
9,11
D16S539
8,12
D18S51
17
D21S11
28,30
D3S1358
17,19
D5S818
12,13
D7S820
10,13
D8S1179
13,15
FGA
19,21
TH01
6
TPOX
8
vWA
15,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.
Clin. Cancer Res. 24:3967-3980(2018).
Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma.
Pham L.V.
Oncotarget 9:346-360(2018).
Establishment and characterization of a novel MYC/BCL2 'double-hit' diffuse large B cell lymphoma cell line, RC.
Jorgensen J.L., Medeiros L.J., Ford R.J. Jr.
J. Hematol. Oncol. 8:121.1-121.11(2015).