YCUB-2Homo sapiens (Human)Cancer cell line
Also known as: Yokohama City University BCP-ALL-2, YcuB2, YCUB2
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_A082 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Disease Information
| Disease | B-lymphoblastic leukemia/lymphoma with t(17;19) |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NR3C1 | p.Ser395Arg (c.1185C>G) | Homozygous | - | PubMed=35124168 |
| Gene fusion | HLF | TCF3-HLF, E2A-HLF | - | In frame | PubMed=11417493 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12
D13S317
8,11
D16S539
9
D18S51
13
D19S433
13
D21S11
29,33.2
D2S1338
20,23
D3S1358
17,18
D5S818
11,12
D7S820
10,11
D8S1179
14,15
FGA
21,22
Penta D
11
Penta E
11,16
TH01
7,8
TPOX
8,9
vWA
18
Publications
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
Minegishi M., Iwamoto S., Sugita K., Inukai T.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Hamanoue S., Shiomi M., Goto S.
Cancer Chemother. Pharmacol. 85:773-783(2020).
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Sugita K., Hosoi H.
Int. J. Hematol. 108:312-318(2018).
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Tada M., Moriuchi T., Sugita K.
Am. J. Hematol. 85:535-537(2010).
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.
Blood 116:962-970(2010).
Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.
Honna H., Kagami K., Goi K., Nakazawa S., Sugita K.
Leukemia 24:865-869(2010).
Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children.
Yanagimachi M., Fujii H., Yokota S., Komine H.
Leuk. Res. 33:1386-1391(2009).