YCUB-4Homo sapiens (Human)Cancer cell line
Also known as: Yokohama City University BCP-ALL-4, YcuB4, YCUB4
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_A083 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Disease Information
| Disease | Precursor B-cell acute lymphoblastic leukemia |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | BCL9 | MEF2D-BCL9 | - | MEF2D exon5/BCL9 exon 9 fusion | PubMed=34940123 |
| Gene deletion | CDKN2B | - | Homozygous | - | PubMed=35933914 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,11
D13S317
8
D16S539
9,11
D18S51
17,18
D19S433
13,14
D21S11
31,33.2
D2S1338
17,22
D3S1358
15,17
D5S818
12,13
D7S820
10,11
D8S1179
16
FGA
25,26
Penta D
10,11
Penta E
17,21
TH01
7,9
TPOX
8,11
vWA
14,16
Publications
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
Minegishi M., Iwamoto S., Sugita K., Inukai T.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Quentmeier H., Pommerenke C., Drexler H.G.
Curr. Issues Mol. Biol. 43:2147-2156(2021).
Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Hamanoue S., Shiomi M., Goto S.
Cancer Chemother. Pharmacol. 85:773-783(2020).
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Sugita K., Hosoi H.
Int. J. Hematol. 108:312-318(2018).