Ma-Mel-27Homo sapiens (Human)Cancer cell line
Also known as: MaMel27, Ma-Mel 27, Ma-Mel_27
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_A163 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Hypodermis[UBERON:UBERON_0002072] |
Donor Information
| Age | 58 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Acral lentiginous melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source ID | ACH-001953_source |
|---|
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NRAS | p.Gly12Asp (c.35G>A) | Unspecified | Somatic | Wistar |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
8,11
D16S539
11,14
D3S1358
16,18
D5S818
12
D7S820
10,12
FGA
20,21
TH01
9.3
TPOX
8,11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Borg A., Pawelec G., Guldberg P.
Mol. Cancer Res. 11:1166-1178(2013).
TERT promoter mutations in familial and sporadic melanoma.";
Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
Science 339:959-961(2013).
Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study.
Hemminki K., Schadendorf D., Kumar R.
Genes Chromosomes Cancer 49:733-745(2010).
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
Schadendorf D.
PLoS ONE 2:E236-E236(2007).