Ma-Mel-46Homo sapiens (Human)Cancer cell line
Also known as: Ma-Mel 46, Ma-Mel_46
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_A181 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Hypodermis[UBERON:UBERON_0002072] |
Donor Information
| Age | 51 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Melanoma |
|---|---|
| Lineage | Skin |
| Subtype | Melanoma |
| OncoTree Code | MEL |
DepMap Information
| Source ID | ACH-001949_source |
|---|
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TERT | c.1-146C>T (c.250C>T) (C250T) | Unspecified | In promoter | PubMed=31068700 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
11
D3S1358
15
D5S818
12
D7S820
8,10
FGA
19,25
TH01
7
TPOX
8
vWA
18,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
TERT promoter mutations in familial and sporadic melanoma.";
Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
Science 339:959-961(2013).
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
Schadendorf D.
PLoS ONE 2:E236-E236(2007).