ZR-75-1 GDC-0941-resistantHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_A1FN |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Disease Information
| Disease | Invasive breast carcinoma of no special type |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | PTEN | p.Leu108Arg (c.323T>G) | Homozygous | - | from parent cell line ZR-75-1 |
| MutationSimple | PIK3CB | p.Asp1067Tyr (c.3199G>T) | Heterozygous | Responsible for pictrelisib resistance | PubMed=26759240 |
| MutationSimple | HRAS | p.Glu162Lys (c.484G>A) | Homozygous | - | from parent cell line ZR-75-1 |