HCC2108Homo sapiens (Human)Cancer cell line
Also known as: Hamon Cancer Center 2108, HCC-2108
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_A352 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 59 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Lung adenocarcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Adenocarcinoma |
| OncoTree Code | LUAD |
DepMap Information
| Source Type | KCLB |
|---|---|
| Source ID | ACH-000314_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly154Val (c.461G>T) | Homozygous | - | Unknown |
| MutationSimple | KRAS | p.Gln61His (c.183A>T) | Unspecified | - | DOI=10.6342/NTU.2004.01000 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
11
D16S539
12
D18S51
16
D19S433
13
D21S11
28,30
D2S1338
19
D3S1358
15
D5S818
11,13
D7S820
9,11
D8S1179
12,13
FGA
22
Penta D
10,13
Penta E
12
TH01
7,9
TPOX
10,11
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
Aldige C.R., Wistuba I.I., Minna J.D.
J. Cell. Biochem. 121:3986-3999(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Posner B.A., Minna J.D., Kim H.S., White M.A.
Cell 173:864-878.e29(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Comparison of features of human lung cancer cell lines and their corresponding tumors.
Ashfaq R., Minna J.D., Gazdar A.F.
Clin. Cancer Res. 5:991-1000(1999).