SCMC-RM2Homo sapiens (Human)Cancer cell line
Also known as: Saitama Children's Medical Center-RhabdoMyosarcoma 2, SCMCRM2, SCMC-R-2, SCMC-RM-2, SCMC-RMZ
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_A667 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 11 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
| Subtype Features | PAX3-FKHR |
Disease Information
| Disease | Embryonal rhabdomyosarcoma |
|---|---|
| Lineage | Soft Tissue |
| Subtype | Alveolar Rhabdomyosarcoma |
| OncoTree Code | ARMS |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001184_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | FOXO1 | PAX3-FOXO1, PAX3-FKHR | - | Not found in original tumor | from parent cell line Rh30 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
9,11,12
D16S539
10,11
D18S51
11,13
D21S11
30,33.2
D3S1358
15,16
D5S818
11,12
D7S820
11,12
D8S1179
14,15
FGA
19,27
Penta D
9
Penta E
11,20,22
TH01
6,9
TPOX
8
vWA
14,18
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Linardic C.M.
Front. Oncol. 3:183.1-183.12(2013).
Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array.
Ogawa S.
Cancer Sci. 104:856-864(2013).
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.
Borsu L., Barr F.G., Ladanyi M.
Clin. Cancer Res. 18:748-757(2012).
Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development.
Pritchard-Jones K., Kool M., Shipley J.M.
Genes Chromosomes Cancer 48:455-467(2009).
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
Hayashi Y.
J. Pediatr. Surg. 42:2040-2045(2007).
Characterization of an embryonal rhabdomyosarcoma cell line showing amplification and over-expression of the N-myc oncogene.
Kemshead J.T., Inaba T., Hanada R., Yamamoto K., Gown A.M., Sawada T.
Int. J. Cancer 45:705-711(1990).
Operation of the JCRB cell bank and isoenzyme.";
Mizusawa H.
Seibutsu Butsuri Kagaku 34:289-292(1990).