YUGEN8Homo sapiens (Human)Cancer cell line
Also known as: YUGEN 8, YUGEN-8
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_A744 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain[UBERON:UBERON_0000955] |
Disease Information
| Disease | Melanoma |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Publications
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Schlessinger J., Lifton R.P., Halaban R.
Nat. Genet. 47:996-1002(2015).
Integrated analysis of tumor samples sheds light on tumor heterogeneity.
Kluger Y.
Yale J. Biol. Med. 85:347-361(2012).
Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies.
Xu F., Li P.-N., Halaban R., Kluger Y.
BMC Genomics 12:230.1-230.14(2011).
MicroRNA signatures differentiate melanoma subtypes.";
Krauthammer M., Tuck D., Slack F.J., Weidhaas J.B.
Cell Cycle 10:1845-1852(2011).
PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.
Krauthammer M., McCusker J.P., Kluger Y., Sznol M.
Pigment Cell Melanoma Res. 23:190-200(2010).