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YUSIT1Homo sapiens (Human)Cancer cell line

Also known as: YUSIT, Yusiti, YUSITI, Yusit-1, YUSIT 1, YUSIT-1

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_A747
SpeciesHomo sapiens (Human)
Tissue SourceNot specified

Disease Information

DiseaseMelanoma

DepMap Information

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleBRAFp.Val600Lys (c.1798_1799delGTinsAA)Heterozygous-from parent cell line YUSIT1

Publications

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.

Schlessinger J., Lifton R.P., Halaban R.

Nat. Genet. 47:996-1002(2015).

DOIPubMedPMC

Integrated analysis of tumor samples sheds light on tumor heterogeneity.

Kluger Y.

Yale J. Biol. Med. 85:347-361(2012).

PubMedPMC

PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.

Krauthammer M., McCusker J.P., Kluger Y., Sznol M.

Pigment Cell Melanoma Res. 23:190-200(2010).

DOIPubMedPMC

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells.

Setaluri V., Hebert D.N.

Proc. Natl. Acad. Sci. U.S.A. 94:6210-6215(1997).

DOIPubMedPMC