Z-138Homo sapiens (Human)Cancer cell line

Also known as: Z138

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database ID	CVCL_B077
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	70
Age Category	Adult
Sex	Male

Disease Information

Disease	Mantle cell lymphoma
Lineage	Lymphoid
Subtype	Mantle Cell Lymphoma
OncoTree Code	MCL

DepMap Information

Source Type	ATCC
Source ID	ACH-002500_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TRAF2	p.Trp114Ter (c.341G>A)	Unspecified	-	PubMed=24362935

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,11

D13S317

9,12

D16S539

D18S51

14,18

D19S433

12,14

D21S11

30,32.2

D2S1338

D3S1358

D5S818

11,13

D7S820

D8S1179

8,13

FGA

20,22

Penta D

13,15

Penta E

7,18

TH01

TPOX

vWA

15,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.

Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.

Clin. Cancer Res. 24:3967-3980(2018).

DOI PubMed

Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma.

Touzeau C., Le Gouill S., Amiot M., Pellat-Deceunynck C.

Blood 128:2808-2818(2016).

DOI PubMed

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.

Isik E., Letai A.G., Lossos I.S.

Blood 126:1555-1564(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.

Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.

Cytometry A 87:285-288(2015).

DOI PubMed

Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.

O'Connor O.A.

Leuk. Lymphoma 56:2114-2122(2015).

DOI PubMed

Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.

Lenz G., Stegmeier F.

Nat. Med. 20:87-92(2014).

DOI PubMed

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.

Martinez-Climent J.A.

Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011).

DOI PubMed PMC

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.

Martinez-Climent J.A.

Blood 109:271-280(2007).

DOI PubMed

Z-138 cell line was derived from a patient with blastoid variant mantle cell lymphoma.

Medeiros L.J., Estrov Z., Rassidakis G.Z.

Leuk. Res. 30:497-501(2006).

DOI PubMed

Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of mantle cell lymphoma.

Williams M.E.

Leuk. Res. 30:449-457(2006).

DOI PubMed

Z-138: a new mature B-cell acute lymphoblastic leukemia cell line from a patient with transformed chronic lymphocytic leukemia.

Hirsch-Ginsberg C.F., Huh Y.O., Yee G., Kurzrock R.

Leuk. Res. 22:341-353(1998).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI