UWB1.289Homo sapiens (Human)Cancer cell line
Also known as: UWB1289, UWB1-289
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_B079 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 56 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Hereditary breast and ovarian cancer syndrome |
|---|---|
| Lineage | Ovary/Fallopian Tube |
| Subtype | Serous Ovarian Cancer |
| OncoTree Code | SOC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001418_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRCA1 | p.Asp825Glufs*21 (c.2475delC) | Heterozygous | - | PubMed=17259345 |
| Gene deletion | BRCA1 | - | Heterozygous | - | PubMed=17259345 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11
D13S317
9
D16S539
12
D18S51
19
D19S433
14,15
D21S11
28,31
D2S1338
19
D3S1358
14,15
D5S818
13
D7S820
7,10
D8S1179
11,12
FGA
22
Penta D
10
Penta E
8
TH01
9
TPOX
9,11
vWA
16,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
High-throughput and sensitive immunopeptidomics platform reveals profound interferon gamma-mediated remodeling of the human leukocyte antigen (HLA) ligandome.
Gfeller D., Coukos G., Bassani-Sternberg M.
Mol. Cell. Proteomics 17:533-548(2018).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
Helleman J.
PLoS ONE 9:E103988-E103988(2014).