TTC-442Homo sapiens (Human)Cancer cell line
Also known as: A91, TU-442, TC-442, TTC442
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_B255 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age | 10 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
Disease Information
| Disease | Embryonal rhabdomyosarcoma |
|---|---|
| Lineage | Soft Tissue |
| Subtype | Embryonal Rhabdomyosarcoma |
| OncoTree Code | ERMS |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001750_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
11,12
D16S539
11,14
D18S51
15,24
D19S433
13,16.2
D21S11
29
D2S1338
20,21
D3S1358
16,18
D5S818
10,11
D7S820
10,13
D8S1179
11,14
FGA
27
TH01
9
TPOX
8,11
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Surfaceome profiling of cell lines and patient-derived xenografts confirm FGFR4, NCAM1, CD276, and highlight AGRL2, JAM3, and L1CAM as surface targets for rhabdomyosarcoma.
Sala R., Heller M., Rossler J., Bernasconi M.
Int. J. Mol. Sci. 24:2601.1-2601.28(2023).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Linardic C.M.
Front. Oncol. 3:183.1-183.12(2013).
Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.
Sokolowski E., Turina C.B., Kikuchi K., Langenau D.M., Keller C.
Oncogene 33:1877-1889(2014).
Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.
Wai D.H., Lawlor E.R., Triche T.J., Pallen C.J., Dunn S.E.
Mol. Cancer Ther. 8:3024-3035(2009).
Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors.
DeCristofaro M.F., Betz B.L., Wang W.-D., Weissman B.E.
Oncogene 18:7559-7565(1999).
Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene.
Triche T.J.
Cancer Res. 55:1385-1392(1995).