SU-CCS-1Homo sapiens (Human)Cancer cell line
Also known as: SUCCS1, SU-CCS1, Su CCS-1, Su-ccs-1
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_B470 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 16 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
Disease Information
| Disease | Soft tissue sarcoma |
|---|---|
| Lineage | Soft Tissue |
| Subtype | Clear Cell Sarcoma |
| OncoTree Code | CCS |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001667_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | ATF1 | EWSR1-ATF1, EWS-ATF | - | Type 2: EWSR1 exon 5 fused to ATF1 exon 5 | PubMed=12237889 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
8
D16S539
11
D18S51
12,16
D19S433
12,14
D21S11
28,30
D2S1338
16,20
D3S1358
15,18
D5S818
12,14
D7S820
12
D8S1179
10
FGA
22.2,24
Penta D
9,12
Penta E
12
TH01
6,7
TPOX
8,11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
Loading cohorts...
Full DepMap dataset with combined data across cell lines
Loading gene expression data...
Publications
Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma.
Berlow N.E., Schoffski P., Keller C.
Br. J. Cancer 128:1941-1954(2023).
Trabectedin is a promising antitumor agent potentially inducing melanocytic differentiation for clear cell sarcoma.
Yoshikawa H., Naka N.
Cancer Med. 6:2121-2130(2017).
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.
Linehan W.M., Kung A.L.-J., Fisher D.E.
Cancer Cell 9:473-484(2006).
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Gabbert H.E., Poremba C.
Cancer Res. 64:3395-3405(2004).
The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma.
Hiraga H., Nojima T., Nagashima K., Schaefer K.-L., Lee K.A.W.
Br. J. Cancer 89:1072-1078(2003).
Promoters containing ATF-binding sites are de-regulated in cells that express the EWS/ATF1 oncogene.
Brown A.D., Lopez-Terrada D.H., Denny C.T., Lee K.A.W.
Oncogene 10:1749-1756(1995).
Use of a newly established human cell line (SU-CCS-1) to demonstrate the relationship of clear cell sarcoma to malignant melanoma.
Epstein A.L., Martin A.O., Kempson R.
Cancer Res. 44:1265-1274(1984).