YURIFHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_B485 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Thigh, hypodermis[UBERON:UBERON_0002072] |
Disease Information
| Disease | Cutaneous melanoma |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRAF | p.Val600Lys (c.1798_1799delGTinsAA) | Heterozygous | - | from parent cell line YUSIT1 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,13
D13S317
11,14
D16S539
12
D18S51
13,16
D21S11
28,30
D3S1358
15,18
D5S818
11,12
D7S820
10
D8S1179
10,13
FGA
22,23
Penta D
11,12
Penta E
11,14
TH01
6
TPOX
8,11
vWA
15,16
Publications
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Schlessinger J., Lifton R.P., Halaban R.
Nat. Genet. 47:996-1002(2015).
Integrated analysis of tumor samples sheds light on tumor heterogeneity.
Kluger Y.
Yale J. Biol. Med. 85:347-361(2012).
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Lifton R.P., Schlessinger J., Boggon T.J., Halaban R.
Nat. Genet. 44:1006-1014(2012).
Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies.
Xu F., Li P.-N., Halaban R., Kluger Y.
BMC Genomics 12:230.1-230.14(2011).
MicroRNA signatures differentiate melanoma subtypes.";
Krauthammer M., Tuck D., Slack F.J., Weidhaas J.B.
Cell Cycle 10:1845-1852(2011).