YUROBHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_B486 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Abdominal wall[UBERON:UBERON_0003697] |
Disease Information
| Disease | Cutaneous melanoma |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | HRAS | p.Gln61Lys (c.181C>A) | Unspecified | - | PubMed=26214590 |
Publications
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Schlessinger J., Lifton R.P., Halaban R.
Nat. Genet. 47:996-1002(2015).
Integrated analysis of tumor samples sheds light on tumor heterogeneity.
Kluger Y.
Yale J. Biol. Med. 85:347-361(2012).
Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies.
Xu F., Li P.-N., Halaban R., Kluger Y.
BMC Genomics 12:230.1-230.14(2011).
MicroRNA signatures differentiate melanoma subtypes.";
Krauthammer M., Tuck D., Slack F.J., Weidhaas J.B.
Cell Cycle 10:1845-1852(2011).
Phosphoproteomic screen identifies potential therapeutic targets in melanoma.
Muthusamy V., Bosenberg M.W., Krauthammer M., Halaban R., Stern D.F.
Mol. Cancer Res. 9:801-812(2011).