UPMM-2Homo sapiens (Human)Cancer cell line

Also known as: Uveal Primary Melanoma with Monosomy-3 2, UPMM2

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_C294
SpeciesHomo sapiens (Human)
Tissue SourceEye, uvea[UBERON:UBERON_0001768]

Donor Information

Age CategoryUnknown
SexFemale

Disease Information

DiseaseUveal melanoma
LineageEye
SubtypeUveal Melanoma
OncoTree CodeUM

DepMap Information

Source TypeQIMRB Berghofer
Source IDACH-002924_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleGNAQp.Gln209Leu (c.626A>T)Unspecified-PubMed=22236444

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11,13
D13S317
9,12
D16S539
12
D3S1358
17
D5S818
10,11
D7S820
9
FGA
21.2,24
TH01
9,9.3
TPOX
9
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Publications

Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.

Salvi S., Truini M., Poggi A., Pfeffer U.

Eur. J. Cancer 49:3353-3365(2013).

Genetic and molecular characterization of uveal melanoma cell lines.

Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.

Pigment Cell Melanoma Res. 25:182-187(2012).

Novel cell lines derived by long-term culture of primary uveal melanomas.

Nareyeck G., Zeschnigk M., Bornfeld N., Anastassiou G.

Ophthalmologica 223:196-201(2009).

Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3.

Nareyeck G., Zeschnigk M., Prescher G., Lohmann D.R., Anastassiou G.

Exp. Eye Res. 83:858-864(2006).