UPMM-3Homo sapiens (Human)Cancer cell line
Also known as: Uveal Primary Melanoma with Monosomy-3 3, UPMM3
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_C295 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Eye, uvea[UBERON:UBERON_0001768] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Male |
Disease Information
| Disease | Uveal melanoma |
|---|---|
| Lineage | Eye |
| Subtype | Uveal Melanoma |
| OncoTree Code | UM |
DepMap Information
| Source Type | QIMRB Berghofer |
|---|---|
| Source ID | ACH-002925_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | GNAQ | p.Gln209Pro (c.626A>C) | Unspecified | - | PubMed=32430489 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12,13
D13S317
8,11
D16S539
12
D21S11
28,31.2
D5S818
10,11
D7S820
8,11
FGA
19
TH01
7,9.3
TPOX
9,10
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.
Salvi S., Truini M., Poggi A., Pfeffer U.
Eur. J. Cancer 49:3353-3365(2013).
Genetic and molecular characterization of uveal melanoma cell lines.
Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Pigment Cell Melanoma Res. 25:182-187(2012).