Mel202Homo sapiens (Human)Cancer cell line

Also known as: EST128, mel-202, Mel 202, Mel-202, MEL202

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database ID	CVCL_C301
Species	Homo sapiens (Human)
Tissue Source	Eye, uvea[UBERON:UBERON_0001768]

Donor Information

Age Category	Unknown
Sex	Female

Disease Information

Disease	Uveal melanoma
Lineage	Eye
Subtype	Uveal Melanoma
OncoTree Code	UM

DepMap Information

Source Type	ECACC
Source ID	ACH-001554_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	SF3B1	p.Arg625Gly (c.1793C>T)	Unspecified	-	PubMed=24994677
MutationSimple	GNAQ	p.Arg210Lys (c.629G>A)	Unspecified	-	Unknown, PubMed=28018010, PubMed=23851445, PubMed=22236444
MutationSimple	GNAQ	p.Gln209Leu (c.626A>T)	Unspecified	-	PubMed=22236444
MutationSimple	CDKN2A	p.Leu65Argfs*52 (c.194_201del) (p.Pro80fs, c.237_244del)	Unspecified	-	PubMed=23851445

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

11,13

D16S539

11,12

D18S51

12,15

D21S11

30.2,31.2

D3S1358

D5S818

11,12

D7S820

11,12

D8S1179

13,16

FGA

23,24

Penta D

10,11

Penta E

7,13

TH01

TPOX

vWA

18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Uveal melanoma cell lines: where do they come from? (an American Ophthalmological Society thesis).

Jager M.J., Bermudez Magner J.A., Ksander B.R., Dubovy S.R.

Trans. Am. Ophthalmol. Soc. 114:T5-T5(2016).

PubMed PMC

Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.

Roman-Roman S.

Mol. Oncol. 8:1508-1520(2014).

DOI PubMed PMC

Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.

Borg A., Pawelec G., Guldberg P.

Mol. Cancer Res. 11:1166-1178(2013).

DOI PubMed

A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.

Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.

Mol. Cancer Ther. 11:888-897(2012).

DOI PubMed

Genetic and molecular characterization of uveal melanoma cell lines.

Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.

Pigment Cell Melanoma Res. 25:182-187(2012).

DOI PubMed PMC

Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.

Guldberg P., Borg A.

Oncogene 26:4738-4748(2007).

DOI PubMed

Studies of tumor-infiltrating lymphocytes from a human choroidal melanoma.

Ksander B.R., Rubsamen P.E., Olsen K.R., Cousins S.W., Streilein J.W.

Invest. Ophthalmol. Vis. Sci. 32:3198-3208(1991).

PubMed