Mel270Homo sapiens (Human)Cancer cell line

Also known as: Mel 270, Mel-270, MEL270, Mel207

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_C302
SpeciesHomo sapiens (Human)
Tissue SourceEye, uvea[UBERON:UBERON_0001768]

Donor Information

Age62
Age CategoryAdult
SexMale

Disease Information

DiseaseUveal melanoma
LineageEye
SubtypeUveal Melanoma
OncoTree CodeUM

DepMap Information

Source TypeAcademic lab
Source IDACH-002014_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleGNAQp.Gln209Pro (c.626A>C)Unspecified-PubMed=32430489

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11
D13S317
12
D16S539
12
D18S51
19
D21S11
28,29
D3S1358
16
D5S818
12
D7S820
8,9
D8S1179
8,13
FGA
24,26
Penta D
15,16
Penta E
8,10
TH01
6,9
TPOX
10
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Publications

Uveal melanoma cell lines: where do they come from? (an American Ophthalmological Society thesis).

Jager M.J., Bermudez Magner J.A., Ksander B.R., Dubovy S.R.

Trans. Am. Ophthalmol. Soc. 114:T5-T5(2016).

Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.

Salvi S., Truini M., Poggi A., Pfeffer U.

Eur. J. Cancer 49:3353-3365(2013).

A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.

Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.

Mol. Cancer Ther. 11:888-897(2012).

Genetic and molecular characterization of uveal melanoma cell lines.

Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.

Pigment Cell Melanoma Res. 25:182-187(2012).

Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.";

White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J.

Cancer Genet. Cytogenet. 168:11-21(2006).

Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.

Ksander B.R.

Clin. Exp. Metastasis 15:509-518(1997).