OMM2.5Homo sapiens (Human)Cancer cell line
Also known as: Omm1_5, OMM1.5, OMM25, OMM2_5, Omm2.5
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_C307 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age | 62 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Uveal melanoma |
|---|---|
| Lineage | Eye |
| Subtype | Uveal Melanoma |
| OncoTree Code | UM |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-002018_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | GNAQ | p.Gln209Pro (c.626A>C) | Unspecified | - | PubMed=32430489 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
11
D13S317
12
D16S539
12
D18S51
19
D21S11
28,29
D3S1358
16
D5S818
12
D7S820
8,9
D8S1179
8,13
FGA
26
Penta D
15,16
Penta E
8,10
TH01
6,9
TPOX
10
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Uveal melanoma cell lines: where do they come from? (an American Ophthalmological Society thesis).
Jager M.J., Bermudez Magner J.A., Ksander B.R., Dubovy S.R.
Trans. Am. Ophthalmol. Soc. 114:T5-T5(2016).
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Roman-Roman S.
Mol. Oncol. 8:1508-1520(2014).
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.
Salvi S., Truini M., Poggi A., Pfeffer U.
Eur. J. Cancer 49:3353-3365(2013).
Genetic and molecular characterization of uveal melanoma cell lines.
Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Pigment Cell Melanoma Res. 25:182-187(2012).