SK-N-MMHomo sapiens (Human)Cancer cell line
Also known as: SKNMM
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_C8G1 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 8 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
Disease Information
| Disease | Neuroblastoma |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Neuroblastoma |
| OncoTree Code | NBL |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-002922_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys135Phe (c.404G>T) | Heterozygous | - | PubMed=22170099, PubMed=19147553, PubMed=16142320 |
| MutationSimple | ATRX | p.Lys1367Ter (c.4099A>T) | Heterozygous | - | Unknown, PubMed=31631027 |
| MutationUnexplicit | ATRX | Ex1-11del | Heterozygous | - | PubMed=31631027 |
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal gene signatures.
Segura M.F., Dyer M.A., Bernstein E.
Cancer Cell 36:512-527.e9(2019).
Molecular detection of GAGE expression in peripheral blood and bone marrow: utility as a tumor marker for neuroblastoma.
Cheung I.Y., Cheung N.-K.V.
Clin. Cancer Res. 3:821-826(1997).