YCUB-8Homo sapiens (Human)Cancer cell line
Also known as: Yokohama City University BCP-ALL-8, YcuB8, YCUB8
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_D3Z8 |
|---|---|
| Species | Homo sapiens (Human) |
Disease Information
| Disease | B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NSD2 | p.Glu1099Lys (c.3295G>A) | Heterozygous | - | PubMed=35124168 |
| Gene fusion | PBX1 | TCF3-PBX1, E2A-PBX1 | - | - | PubMed=29786757 |
Publications
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
Minegishi M., Iwamoto S., Sugita K., Inukai T.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Hamanoue S., Shiomi M., Goto S.
Cancer Chemother. Pharmacol. 85:773-783(2020).