ZAHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_D596 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Cervical lymph node[UBERON:UBERON_0002429] |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly279Glu (c.836G>A) | Unspecified | - | PubMed=1570156 |
| MutationSimple | HRAS | p.Gly13Arg (c.37G>C) | Unspecified | - | PubMed=2654810 |
Publications
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.
Int. J. Oncol. 32:101-111(2008).
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Kozaki K.-i., Amagasa T., Inazawa J.
Oncogene 26:7921-7932(2007).
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Omura K., Inazawa J.
Cancer Sci. 97:1351-1358(2006).
Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas.
Taki M., Hosokawa H., Nagayama M.
Int. J. Oncol. 22:891-898(2003).
Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo.
Hoteiya T., Hayashi E., Satomura K., Kamata N., Nagayama M.
J. Oral Pathol. Med. 28:107-111(1999).
Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of c-H-ras-1 and concurrent amplifications of c-erbB-1 and c-myc.
Takahashi N., Enomoto S., Tsuchida N.
Oncogene 4:499-505(1989).
Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.
Rikimaru K., Toda H., Tachikawa N., Kamata N., Enomoto S.
In Vitro Cell. Dev. Biol. 26:849-856(1990).
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Sakai E., Tsuchida N.
Oncogene 7:927-933(1992).