ZR-75-1 BCAR1 clone 4A12Homo sapiens (Human)Cancer cell line

Also known as: ZR-75-1 BCAR1 [4A12]

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_E4WT
SpeciesHomo sapiens (Human)
Tissue SourceAscites[UBERON:UBERON_0007795]

Disease Information

DiseaseInvasive breast carcinoma of no special type

DepMap Information

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimplePTENp.Leu108Arg (c.323T>G)Homozygous-from parent cell line ZR-75-1
MutationSimpleHRASp.Glu162Lys (c.484G>A)Homozygous-from parent cell line ZR-75-1

Publications

BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.

Brinkman A., van der Flier S., Kok E.M., Dorssers L.C.J.

J. Natl. Cancer Inst. 92:112-120(2000).