BroLiHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_E997 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Cutaneous neuroendocrine carcinoma |
|---|---|
| Lineage | Skin |
| Subtype | Merkel Cell Carcinoma |
| OncoTree Code | MCC |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001019_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
10,12
D13S317
10,12
D16S539
12,13
D18S51
16,19
D21S11
27.2,29.2
D3S1358
17,18
D5S818
10,11
D7S820
9,11
D8S1179
11,17
FGA
20,26
Penta D
13
Penta E
10
TH01
6,9
TPOX
8,11
vWA
17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.
Mitulovic G.
Clin. Proteomics 16:42.1-42.13(2019).
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.
Int. J. Cancer 145:1020-1032(2019).
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.
Oncotarget 7:32956-32968(2016).
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
J. Invest. Dermatol. 133:2453-2460(2013).
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.";
Landthaler M., Becker J.C.
PLoS ONE 7:E31255-E31255(2012).