TC-106Homo sapiens (Human)Cancer cell line
Also known as: TC106
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_F531 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Scalp[UBERON:UBERON_0000403] |
Donor Information
| Age | 19 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Subtype Features | EWS-ERG |
Disease Information
| Disease | Ewing sarcoma |
|---|---|
| Lineage | Bone |
| Subtype | Ewing Sarcoma |
| OncoTree Code | ES |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001283_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | BRCA2 | p.Lys3326Ter (c.9976A>T) (10204A>T) | Unspecified | - | PubMed=25010205 |
| Gene fusion | ERG | EWSR1-ERG, EWS-ERG | - | In frame | PubMed=9738976 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
11,13
D13S317
10,11
D16S539
13
D18S51
17,18
D19S433
12
D21S11
29,31.2
D2S1338
24,26
D3S1358
16,17
D5S818
12,13
D7S820
9,10
D8S1179
12,13
FGA
21,22
TH01
9.3
TPOX
8,10
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
PLoS Genet. 10:E1004475-E1004475(2014).
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma.
Israel M.A.
Cancer Res. 48:4307-4311(1988).
Cytogenetic characterization of selected small round cell tumors of childhood.
Tsai S., Israel M.A.
Cancer Genet. Cytogenet. 21:185-208(1986).
Systematic multi-omics profiling of Ewing sarcoma cell lines.";
Orth M.F.
Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.
Tumor cell lines of the peripheral nervous system.";
Israel M.A., Thiele C.J.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).