YUDEDEHomo sapiens (Human)Cancer cell line

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_G322
SpeciesHomo sapiens (Human)
Tissue SourcePretibial, soft tissue[UBERON:UBERON_0034929]

Disease Information

DiseaseCutaneous melanoma

DepMap Information

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleNRASp.Gln61His (c.183A>T)Unspecified-PubMed=26214590

Publications

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.

Schlessinger J., Lifton R.P., Halaban R.

Nat. Genet. 47:996-1002(2015).

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.

Lifton R.P., Schlessinger J., Boggon T.J., Halaban R.

Nat. Genet. 44:1006-1014(2012).

PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.

Krauthammer M., McCusker J.P., Kluger Y., Sznol M.

Pigment Cell Melanoma Res. 23:190-200(2010).