YUFICHomo sapiens (Human)Cancer cell line

AI Summary

No AI-generated summary available for this cell line.

Basic Information

Database IDCVCL_G324
SpeciesHomo sapiens (Human)
Tissue SourceLymph node[UBERON:UBERON_0000029]

Disease Information

DiseaseCutaneous melanoma

DepMap Information

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleNRASp.Gln61Arg (c.182A>G)Unspecified-PubMed=26214590

Publications

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.

Schlessinger J., Lifton R.P., Halaban R.

Nat. Genet. 47:996-1002(2015).

MicroRNA signatures differentiate melanoma subtypes.";

Krauthammer M., Tuck D., Slack F.J., Weidhaas J.B.

Cell Cycle 10:1845-1852(2011).

PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.

Krauthammer M., McCusker J.P., Kluger Y., Sznol M.

Pigment Cell Melanoma Res. 23:190-200(2010).