YMHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_IU39 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Disease Information
| Disease | Diffuse large B-cell lymphoma |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | BCL6 | BCL6-IL21R | - | - | PubMed=12967475, PubMed=11821949 |
| Gene fusion | BCL2 | IGL-BCL2 | - | - | PubMed=12967475 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
9,11
D16S539
9,10
D18S51
13,14,17
D19S433
14
D21S11
29
D2S1338
17,19
D3S1358
15
D5S818
12,13
D7S820
8,11
D8S1179
12,15
FGA
24
Penta D
9,12
Penta E
5,11
TH01
7,9.3
TPOX
8,9
vWA
17,18
Publications
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Leuk. Lymphoma 57:1015-1020(2016).
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Maesako Y., Uchiyama T., Ohno H.
Cancer Sci. 94:774-781(2003).
The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma.
Ichinohasama R., Imada K., Uchiyama T., Ohno H.
Oncogene 21:368-376(2002).
Heterogeneous breakpoints on the immunoglobulin genes are involved in fusion with the 5' region of BCL2 in B-cell tumors.
Yonetani N., Ueda C., Akasaka T., Nishikori M., Uchiyama T., Ohno H.
Jpn. J. Cancer Res. 92:933-940(2001).
Molecular features of a new human lymphoma cell line carrying both BCL2 and BCL6 gene rearrangements.
Takahashi N., Miyanishi S., Okumura A., Muramatsu M., Fukuhara S.
Oncogene 17:971-979(1998).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).