Z-181Homo sapiens (Human)Cancer cell line
Also known as: Z181
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_IU89 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 32 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Subtype Features | BCR-ABL1 |
Disease Information
| Disease | B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) |
|---|---|
| Lineage | Lymphoid |
| Subtype | B-Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2);BCR-ABL1 |
| OncoTree Code | BLLBCRABL1 |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-003103_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | ABL1 | BCR-ABL1, BCR-ABL | - | BCR exon 1 fused to ABL1 exon 2 | PubMed=10576511, PubMed=10071072, PubMed=8751477 |
Gene Expression Profile
Gene expression levels and statistical distribution
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Publications
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
Leuk. Res. 23:1055-1060(1999).
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leuk. Res. 23:207-215(1999).
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Janssen J.W.G., Drexler H.G.
Leukemia 11:441-447(1997).
Role of granulocyte-macrophage colony-stimulating factor in Philadelphia (Ph1)-positive acute lymphoblastic leukemia: studies on two newly established Ph1-positive acute lymphoblastic leukemia cell lines (Z-119 and Z-181).
Ouspenskaia M.V., Hirsch-Ginsberg C.F., Huh Y.O., Yee G., Kurzrock R.
J. Cell. Physiol. 166:618-630(1996).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).