YUCLATHomo sapiens (Human)Cancer cell line
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_J518 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Not specified |
Disease Information
| Disease | Cutaneous melanoma |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NF1 | p.Ser2496Phe (c.7487C>T) | Unspecified | - | PubMed=26214590 |
| MutationSimple | BRAF | p.Val600Lys (c.1798_1799delGTinsAA) | Heterozygous | - | from parent cell line YUSIT1 |
Publications
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Schlessinger J., Lifton R.P., Halaban R.
Nat. Genet. 47:996-1002(2015).
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Lifton R.P., Schlessinger J., Boggon T.J., Halaban R.
Nat. Genet. 44:1006-1014(2012).