CHLA-9Homo sapiens (Human)Cancer cell line
Also known as: CHLA9
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_M150 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Thorax[UBERON:UBERON_0000915] |
Donor Information
| Age | 14 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
| Subtype Features | EWS-FLI |
Disease Information
| Disease | Primitive neuroectodermal tumor |
|---|---|
| Lineage | Bone |
| Subtype | Ewing Sarcoma |
| OncoTree Code | ES |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001034_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | STAG2 | p.Val628insThrAspIle | Unspecified | - | PubMed=25010205 |
| Gene fusion | EWSR1 | EWSR1-FLI1, EWS-FLI1 | - | Type 1 fusion | PubMed=15150091 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
11,12
D16S539
11
D18S51
12,14
D19S433
12,13
D21S11
28,29
D2S1338
19,20
D3S1358
15,16
D5S818
12
D7S820
9,10
D8S1179
10,13
FGA
23,24
TH01
7,9.3
TPOX
8,11
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
PLoS Genet. 10:E1004475-E1004475(2014).
Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.
Jenabi J., Ji L.-Y., Triche T.J., Lawlor E.R., Reynolds C.P.
PLoS ONE 8:E80060-E80060(2013).
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Reynolds C.P.
Pediatr. Blood Cancer 56:239-249(2011).