CHLA-32Homo sapiens (Human)Cancer cell line
Also known as: CHLA32
AI Summary
No AI-generated summary available for this cell line.
Basic Information
| Database ID | CVCL_M151 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 8 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
| Subtype Features | EWS-FLI |
Disease Information
| Disease | Primitive neuroectodermal tumor |
|---|---|
| Lineage | Bone |
| Subtype | Ewing Sarcoma |
| OncoTree Code | ES |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001032_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg342Ter (c.1024C>T) | Homozygous | - | PubMed=29970484 |
| Gene fusion | EWSR1 | EWSR1-FLI1, EWS-FLI1 | - | Type 1 fusion | PubMed=15150091 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10,11
D13S317
12
D16S539
12
D18S51
18,19
D19S433
13,15
D21S11
28,31
D2S1338
24
D3S1358
16
D5S818
11
D7S820
8,9
D8S1179
13,15
FGA
24
TH01
6,9.3
TPOX
8,10
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
PLoS Genet. 10:E1004475-E1004475(2014).
Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.
Jenabi J., Ji L.-Y., Triche T.J., Lawlor E.R., Reynolds C.P.
PLoS ONE 8:E80060-E80060(2013).